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Data from: Relaxin reverses inflammatory and immune signals in aged hearts
Internal Dataset

UID: 82

Author(s): Martin, Brian+, Gabris-Weber, Beth Ann+, Romero, Guillermo+, Chattopadhyay, Ansuman+, Salama, Guy*+ * Corresponding Author + University of Pittsburgh Author
Description
Examination of effect of Relaxin (RLX) treatment on young (9-month) and aged (24-month) rats to test the hypothesis that RLX acts at a genomic level to reverse maladaptive remodeling in aging and heart failure. Treatment was 0.4 mg/kg/day RLX for 2-weeks delivered by subcutaneous osmotic mini-pumps or with sodium acetate (controls). There are twenty-one NCBI GEO records, 4 female and 3 male each for young and aged controls and aged RLX treated. Raw data available in SRA; processed data in supplementary file.
Subject of Study
Rats

Species (Strain): Brown Norway (Fischer 344)
Tissue/Cell Line: Heart, left ventricular

Subject Sex
Male
Female
Keywords
Aging
Atrial Fibrillation
Biomarkers
Cardiovascular Diseases
Heart Failure
Inflammation
Macrophage
Relaxin
Sequence Analysis, RNA
Access via NCBI Geo

Expression profiling by high throughput sequencing
Accession #: GSE106377

Access via SRA

Raw data for 21 samples.
Accession #: SRP123212

Access via BioProject

Overall project information and data.
Accession #: PRJNA416509

Access Restrictions
Free to all
Access Instructions
The NCBI Gene Expression Omnibus, Sequence Read Archive, and BioProject databases provide open access to these files.
Associated Publications
Martin B, Gabris-Weber BA, Reddy R, Romero G, Chattopadhyay A, Salama G. Relaxin reverses inflammatory and immune signals in aged hearts. PLoS One. 2018 Jan 18;13(1):e0190935. doi: 10.1371/journal.pone.0190935. PMID: 29346407; PMCID: PMC5773192.
Data Type
Genetic/Genomic
Equipment Used
Illumina NextSeq 500

High-throughput sequencer for exomes, whole genomes, and transcriptomes

Software Used
Biomedical Genomics Workbench, 3.0.1

Commerical tool for NGS data analysis for biomarker discovery.

Ingenuity Pathway Analysis

For modeling, analyzing, and understanding complex 'omics data

MetaCore

Molecular pathway analysis

Dataset Format(s)
SOFT (.soft), MINiML (.miniml, .xml), TXT (.txt)
Resource Type(s)
Dataset
Grant Support
Winters Foundation Award/Samuel and Emma Winters Foundation
Bridge Funding Award/Office of the Senior Vice Chancellor - Health Sciences, University of Pittsburgh
Innovator Award/Vascular Medicine Institute/Heart and Vascular Institute of the University of Pittsburgh
Data Catalog Record Updated
2021-12-16

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