Data from: Relaxin reverses inflammatory and immune signals in aged hearts
Internal Dataset

UID: 82

Author(s): Martin, Brian+, Gabris-Weber, Beth Ann+, Romero, Guillermo+, Chattopadhyay, Ansuman+, Salama, Guy*+ * Corresponding Author + University of Pittsburgh Author
Examination of effect of Relaxin (RLX) treatment on young (9-month) and aged (24-month) rats to test the hypothesis that RLX acts at a genomic level to reverse maladaptive remodeling in aging and heart failure. Treatment was 0.4 mg/kg/day RLX for 2-weeks delivered by subcutaneous osmotic mini-pumps or with sodium acetate (controls). There are twenty-one NCBI GEO records, 4 female and 3 male each for young and aged controls and aged RLX treated. Raw data available in SRA; processed data in supplementary file.
Subject of Study
Subject Sex
Access via NCBI Geo

Expression profiling by high throughput sequencing
Accession #: GSE106377

Access via SRA

Raw data for 21 samples.
Accession #: SRP123212

Access via BioProject

Overall project information and data.
Accession #: PRJNA416509

Access Restrictions
Free to all
Access Instructions
The NCBI Gene Expression Omnibus, Sequence Read Archive, and BioProject databases provide open access to these files.
Associated Publications
Data Type
Equipment Used
Illumina NextSeq 500
Software Used
Biomedical Genomics Workbench, 3.0.1
Ingenuity Pathway Analysis
Dataset Format(s)
SOFT (.soft), MINiML (.miniml, .xml), TXT (.txt)
Resource Type(s)
Grant Support
Winters Foundation Award/Samuel and Emma Winters Foundation
Bridge Funding Award/Office of the Senior Vice Chancellor - Health Sciences, University of Pittsburgh
Innovator Award/Vascular Medicine Institute/Heart and Vascular Institute of the University of Pittsburgh
Data Catalog Record Updated

Notice and Disclaimer: Please note that the information in this catalog is provided as a courtesy, as is, and with no representations or warranties of any kind. When you contact the responsible individual(s) listed in each record, or, where applicable, access a data repository listed, you will be subject to terms and conditions required by the data custodian/data repository. The University of Pittsburgh does not attempt to judge the scholarly quality of the data referenced and relies on the judgment and research expertise of those who created and/or deposited it.