UID: 92
This Github repository contains a bioinformatics pipeline for identification and characterization of mutations in Saccharomyces cerevisiae. MutantHuntWGS compares data, input in FASTQ format, from a mutant strain to a wild-type strain to identify high confidence sequence variants present only in the mutant.
To enable quick and easy installation and to ensure reproducibility, MutantHuntWGS was incorporated into a Docker container. With a single command, users can download and install the software. A second command runs the analysis. The pipeline allows researchers to leverage WGS for the efficient identification of causal mutations, regardless of bioinformatics experience.
Species (Strain): Saccharomyces cerevisiae
Bioinformatics pipeline including Docker, code, FASTQ files.
Utilities for variant calling and manipulating VCFs and BCFs.
Tool for aligning sequencing reads to long reference sequences.
Software platform to containerize, distribute, and download software packages.
Suite of programs for interacting with high-throughput sequencing data.
Predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids.
Genetic variant annotation and functional effect prediction toolbox.
Provides easily accessible methods for working with complex genetic variation data in the form of VCF files.
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