Targeted deletion of astrocytic Nhe1 stimulates Wnt/β-catenin-mediated BBB repair and angiogenesis after ischemic stroke
Internal Dataset

UID: 98

Author(s): Begum, Gulnaz*+, Sun, Dandan+, Chattopadhyay, Ansuman+, Chaparala, Srilakshmi+ * Corresponding Author + University of Pittsburgh Author
Examination of effect of deletion of astrocytic Na+/H+ exchanger isoform 1 (Nhe1) on post-stroke recovery and vascular repair. Expression profiling by high throughput sequencing of astrocytes from Gfap-CreERT2+/-;Nhe1f/f mouse brains, 24 hours after transient middle cerebral artery occlusion. Twelve NCBI GEO records: 3 samples each from Wild-type and Nhe1 Astro-KO, both contralateral and ipsilateral. Raw data available in SRA; processed data in supplementary file.
Subject of Study
Subject Sex
Access via GEO

Expression profiling by high throughput sequencing.
Accession #: GSE145839

Access via SRA

Raw data for 12 samples.
Accession #: SRP250557

Access via BioProject

Overall project information and data.
Accession #: PRJNA608486

Access Restrictions
Free to all
Access Instructions
The NCBI Gene Expression Omnibus, Sequence Read Archive, and BioProject databases provide open access to these files.
Associated Publications
Data Type
Equipment Used
Illumina HiSeq 2500
Software Used
CLC Genomics Workbench, Version: 10.1.1
DAVID, Version: 6.8
Ingenuity Pathway Analysis
Dataset Format(s)
SOFT (.soft), MINiML (.miniml, .xml), TXT (.txt)
Resource Type(s)
Grant Support
Data Catalog Record Updated

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