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  • Internal Dataset

    Transcriptomic profiles of mycobacteriophage D29, L5 and StarStuff

    Authors
    • Hatfull, Graham F.
    • Dedrick, Rebekah M.
    • Mavrich, Travis N.
    • Garlena, Becky
    Description

    This dataset contains twelve high throughput sequenced gene expression profiles of mycobacterium smegmatis infected with (1) mycobacteriophage D29 at 15min, 30min, 60min, and 150min, (2) mycobacteriophage StarStuff itself and at 15min, 30min, 60min, and 150min, and (3) mycobacteriophage L5 itself and at 30min and 150 min. Total RNA was isolated, depleted of rRNA, and library prepped.

    Keywords
    • Bacteriophage evolution
    • Evolution, Molecular
    • Gene Expression Profiling
    • Mycobacterium
    • Sequence Analysis, RNA
    Access Rights
    Free to all
  • Internal Dataset

    Data from: SARS-CoV-2 Infections - Gene Expression Omnibus (GEO) Data Mining, Pathway Enrichment Analysis, and Prediction of Potentially Repurposable Drugs

    Authors
    • Chaparala, Srilakshmi
    • Iwema, Carrie L.
    • Chattopadhyay, Ansuman
    Description

    This project describes a protocol to analyze publicly available transcriptomic data from the NCBI Gene Expression Database (GEO) using in silico approach. This involved identifying SARS-CoV-2 infection-induced differentially Expressed (DE) genes from human gene mapping and viral mapping, statistically enriched pathway associations, and potentially repurposable drugs for COVID-19 treatment. Further...

    Keywords
    • COVID-19
    • Gene Expression Profiling
    • SARS-CoV-2
    • Sequence Analysis, RNA
    • Transcriptomics
    • Virus Diseases
    Access Rights
    Free to all
  • Internal Dataset

    Targeted deletion of astrocytic Nhe1 stimulates Wnt/β-catenin-mediated BBB repair and angiogenesis after ischemic stroke

    Authors
    • Begum, Gulnaz
    • Sun, Dandan
    • Chattopadhyay, Ansuman
    • Chaparala, Srilakshmi
    Description

    Examination of effect of deletion of astrocytic Na+/H+ exchanger isoform 1 (Nhe1) on post-stroke recovery and vascular repair. Expression profiling by high throughput sequencing of astrocytes from Gfap-CreERT2+/-;Nhe1f/f mouse brains, 24 hours after transient middle cerebral artery occlusion. Twelve NCBI GEO records: 3 samples each from Wild-type and Nhe1 Astro-KO, both contralateral and ipsilateral....

    Keywords
    • Angiogenesis
    • Astrocytes
    • Blood-Brain Barrier
    • Cerebrovascular Circulation
    • Gene Expression Profiling
    • High-Throughput Nucleotide Sequencing
    • Ischemic Stroke
    • Mus musculus
    • RNA-Seq
    Access Rights
    Free to all